WHO/REAL Classification
1995年にthe Society for Hematopathology and teh European Association of Hematopathologistsが合同会議を開催し、WHOのために、分類を決めた。これは、Revised European-American Classification of Lymphoid Neoplasms (REAL)を形態、免疫型、遺伝子型、臨床症状などに基づき、改訂、更新したものである。B細胞、T細胞、ナチュラル・キラー（NK）細胞系の分類と臨床的特徴を統合した分類である。
WHO/REAL Classification of the Non-Hodgkin's Lymphomas Accoding to Clinical Aggressivness
I. The indolent lymphomas : 35-40%を占める。無治療で年の単位の生存が可能。
B-cell neoplasms
Small lymphocytic lymphoma/B-cell chronic lymhocytic leukemia
Lymphoplasmacytic lymphoma (+- Waldenstrom's macroglobulinemia)
Plasma cell myeloma/plasmacytoma
Hairy cell leukemia
Follicular lymphoma (grade I and II)
Marginal zone B-cell lymphoma
Mantle cell lymphoma
T-cell neoplasms
T-cell large granular lymphocyte leukemia
Mycosis fungoides
T-cell prolymphocytic luekemia
Natural killer cell neoplasms
Natural killer cell large granular lymphocyte leukemia
II. The aggressive lymphomas : 50%を占める。無治療で月の単位の生存が可能。
Follicular lymphoma (grade III)
Diffuse large B-cell lymphoma
Peripheral T-cell lymphoma
Anaplastic large cell lymphoma, T/null cell
III. The highly aggressive lymphomas : 5%を占める。無治療で週の単位の生存が可能。
Burkitt's lymphoma
Precursor B lymphoblastic leukemia/lymphoma
Adult T-cell lymphoma/leukemia
Precursor T lymphoblastic leukemia/lymphoma
(Harris NL, Jaffe ES, Diebod J, et al: World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999;17:3835.)
